If you would like to find out more about any of our current and ongoing trials, email research@ncic.nhs.uk or call 01228 603145.

If none of the studies below are suitable, you can visit the Be Part of Research website. Here you can find information about clinical trials and research happening in the UK. 

Study name

Type of study



Add Aspirin

Clinical trial of investigational medicinal product (CTIMP)

University College London

The Add Aspirin study aims to find out if taking aspirin regularly after treatment for early stage cancer, stops or delays the cancer from coming back.




Newcastle upon Tyne Hospitals NHS Foundation Trust

This is a study to collect information about the health and treatment of people with respiratory papillomatosis.



A multi-centre randomised controlled trial (RCT)

North Cumbria Integrated Care NHS Foundation Trust

This study assesses the patient and clinician’s impressions of different 2 layer compression therapies.




Leeds and York Partnership NHS Foundation Trust

This trial is investigating a new treatment for phobias in children and young people. It is investigating the effectiveness of a type of psychological therapy called one session treatment (OST) in comparison to cognitive behavioural therapy (CBT) based treatments.



Study limited to working with human tissue samples, other human biological samples and/or data

Nottingham University Hospitals NHS Trust

The aim of this project is to take DNA from blood or saliva samples in order to look at the genetic variation seen in patients with asthma and work out which genes are important.




University of Manchester

The purpose of this research study is to assess whether the new biological treatments used in the treatment of psoriasis have any side effects when used long term.


Ballad UK


NHS Greater Glasgow and Clyde

This study compares chemotherapy choices after an operation to remove a cancer of the small bowel.


Big Baby


University Hospitals Coventry and Warwickshire NHS Trust

The purpose of this trial is to find out if inducing labour earlier than usual, at 38 weeks, makes it less likely that shoulder dystocia will happen in women whose babies appear to be bigger than expected.




University of Manchester

The purpose of this research is to assess whether some of the biological and other new therapies used in the treatment of rheumatoid arthritis have a greater risk of serious side effects and long term health problems than established treatments.




Integra LifeSciences Corporation

The purpose of this study is to monitor the long term benefits of the Cadence™ Total Ankle System.


Cleft Collective


University of Bristol

This research will help us find out more about the genetic and environmental causes of cleft, the best treatments for cleft and the impact of cleft on the family and the individual.




University of Liverpool

DexEnceph is a study that aims to find out if a 4 day course of dexamethasone reduces the swelling caused by herpes simplex virus encephalitis to improve memory.




North Cumbria Integrated Care NHS Foundation Trust

The aim of this study is to investigate what type of wound dressing, or wound dressing combination, gives the best outcomes to avoid foot ulcer infection and improve healing.




Newcastle upon Tyne Hospitals NHS Foundation Trust

The purpose of this trial is to see whether giving 2 doses of eculizumab to children and young people with shiga toxin–producing e coli (STEC) haemolytic-uremic syndrome (HUS) reduces the severity of their disease.




Newcastle upon Tyne Hospitals NHS Trust

This study is trying to find out if the autonomic nervous system works differently in people with mental health, neurodevelopmental and neurodegenerative disorders.  It studies people with and without these disorders to evaluate whether the autonomic nervous system is affected by the severity of the disorder or by medication use.




University of Oxford

This study is for babies referred for breastfeeding support who are thought to have tongue-tie, in which a piece of skin tightly joins the middle part of the underside of the tongue to the base of the baby’s mouth. The aim of this study is to find out if support for breastfeeding or support for breastfeeding with a frenotomy (dividing this skin which may be limiting movement of the baby’s tongue) helps mothers and their babies to successfully breastfeed.


Genetics of Endocrine Tumours


Queen Mary, University of London

This study aims to identify genes which play a part in the development of endocrine tumours.


Genetics of SLE


King’s College, London

The study will use high-throughput genome sequencing technologies to allow genetic analysis of systemic lupus erythematosus (SLE) through the collection of blood samples.


IBD Bioresource


Cambridge University Hospitals NHS Foundation Trust

The IBD BioResource is part of the NIHR BioResource. It aims to help research the causes of Crohn’s disease and colitis, understand contributing factors to irritable bowel disease (IBD) severity and treatment response, and help to development new treatments.


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Medical Research Council

With this study we’re aiming to find out the best way to give chemotherapy to women with advanced ovarian cancer.


Improving Health at Home Before an Operation



Northumbria University

A questionnaire study of patient opinions on improving their health before surgery.


A cluster RCT

Bradford Teaching Hospitals NHS Foundation Trust

The ISCOMAT study is looking at how people with heart failure can be helped to manage their medicines after they’ve been in hospital.


ITP Registry


Barts Health, London

The aim of this study is to collect data from immune thrombocytopenic purpura (ITP) patients from all over the country, in order to build a broad picture of ITP so that we can see emerging patterns.


Lifestyle Health and Well Being Survey


The University of York

The purpose of this study is to follow adults in the UK who have severe mental ill health and to collect information about their health and general wellbeing. This study will provide valuable up to date information on the health and wellbeing of people with severe mental ill health.



A multi-centre RCT

University of Birmingham

This study will help experts learn if women with low or low-intermediate grade ductal carcinoma in situ (DCIS) (low risk disease – non-invasive breast cancer) can safely avoid surgery.




North Cumbria Integrated Care NHS Foundation Trust

The aim of this study is to assess whether there is a difference in patient satisfaction, patient-related functional outcomes, surgical accuracy and cost implications in high tibial osteotomy performed using either an Opty-Line device or Tomofix device respectively at 12 and 24 months post-surgery.


MCL Biobank

Human Tissue and Data

Plymouth Hospitals NHS Trust

This study aims to establish a Biobank and database as a national resource for characterising indolent and aggressive forms of mantle cell lymphoma (MCL).




Northumberland, Tyne & Wear

NHS Foundation Trust

The main objective of this study is to investigate the acceptability of a new treatment manual for managing unusual sensory experiences (MUSE) in patients with at risk mental states (ARMS) for psychosis.




Newcastle Upon Tyne Hospitals NHS Foundation Trust

This multicentre randomised controlled trial, randomises participants to either septoplasty or medical management of nasal obstruction.




Kompetenznetz Vorhofflimmem e.V

To demonstrate that oral anticoagulation whether the novel oral anticoagulant (NOAC) edoxaban is superior to current therapy to prevent stroke, systemic embolism, or cardiovascular death in patients with atrial high rate episodes (AHRE) but without overt atrial fibrillation (AF).




EURObservational Research Programme

The purpose of this study is to evaluate what sort of treatments patients with non S-T elevation myocardial infarction (NSTEMI) receive in different countries and in different settings. This research will lead to practical recommendations for improvement in the treatment of this disease at local, national and international levels.


Oncotype Dx Node Positive


Hywel Dda University Health Board

This study is looking at patients who have cancers which require high levels of oestrogen in the blood to continue growing and who have breast cancer cells that have travelled from the breast to the lymph nodes located in the armpit.


Optimise II


Queen Mary University of London

A study researching new ways of looking after patients who have surgery, to help them recover to return home sooner and in better health.



A double-blind, randomised, placebo controlled trial

University of Oxford

This study is testing a new medication called inclisiran which helps to lower bad low-density lipoprotein (LDL) cholesterol. The study scientists want to find out if having an injection of inclisiran every 6 months will prevent heart attacks and strokes.




University of Manchester

When a person is treated with one of the biologic drugs for psoriatic arthritis or psoriasis, information is routinely collected to assess whether these new treatments have a greater risk of serious side effects and long term health problems than established treatments. This study aims to find out whether clinical, serological, genetic and psychological factors influence response to treatment.




North Cumbria Integrated Care NHS Foundation Trust

The aim of this study is to determine if the way a patient is positioned shortly after a greater occipital nerve (GON) block affects the effectiveness of the actual GON block treatment.



Other clinical trial to study a novel intervention or randomised clinical trial to compare interventions in clinical practice

Derby Hospitals NHS Foundation Trust

This study aims to find out if adjuvant therapy treatments are just as good at treating cancer and preventing it from coming back as the current standard of adjuvant therapy treatments with armpit treatment.




University College London

Measure patient outcomes after major elective non-cardiac surgery for a sample of patients across the UK.




Queen Mary University of London

In this study we want to find out whether weekly phone calls, together with an ecigarette (EC) or a nicotine patch are effective in helping pregnant women to stop smoking.




The UK Renal Registry

The National Registry of Rare Kidney Diseases (RaDaR) is a research initiative by UK kidney specialists, the Renal Association and the UK Renal Registry. It is designed to gather information from patients with rare kidney diseases.


RCT of COPe support online resource for carers


St George’s, University of London

This is a study developed to look at an online resource called COPe-support (which stands for Carers fOr People with Psychosis e-support).  This study aims to find out if COPe-support works to improve carers’ wellbeing and how well they cope with caring, using a randomised controlled trial design.




Cumbria Partnership NHS Foundation Trust

The purpose of the ROBOT study is to see how effective different treatments are after an osteotomy procedure for the reduction of post-operative swelling and pain.





We are investigating how to test the genes in cancer cells, which we hope may lead to better treatments in the future, in particular by matching the treatments that patients receive to the genetic abnormalities in the cells.




Medical Research Council

A clinical trial which aims to identify new treatments for prostate cancer.




North Cumbria Integrated Care NHS Foundation Trust

This study aims to assess the accuracy of the novel sigma VCM swab processing kit compared to current methods to detect neisseria gonorrhoea in Cumbrian sexual health clinics, and to assess the potential cost effectiveness and benefits in terms of storage, transport and incubation time.


The Adult Autism Spectrum Co-hort


Newcastle University

The aim of this research is to lead to new knowledge about people’s lives, how to change services and support for adults on the autism spectrum and their relatives.


Trial Net


University of Bristol

TrialNet is screening relatives of people with type 1 diabetes to find out if these family members are at risk of developing diabetes.  Screening involves a blood test to see if diabetes related autoantibodies are present.




Royal Devon and Exeter

NHS Foundation Trust

This study aims to understand why some diabetes medicines do not work for some people so that we can help to choose the most effective medicine in the future.



Human Tissue

Newcastle upon Tyne Hospitals NHS Foundation Trust

UK-AIH is a study for adults with confirmed autoimmune hepatitis (AIH) in the UK. It will collect information from any patient who wishes to participate including a blood sample, information from the doctor looking after them, and we’ll ask permission to let researchers use any liver tissue samples that are taken as part of their normal medical care.  All this information will be studied to identify new tests and treatments.



Human Tissue

Institute of Cancer Research

The causes of prostate cancer are unknown and the study aims to recruit 26,000 men to discover why prostate cancer develops.



Clinical Trial (CT) device

North Cumbria Integrated Care NHS Foundation Trust

This study is designed to test the performance of a new test, called glycologic, to detect wound infection earlier than current testing allows.